proin vs incurin

Safely used worldwide for more than 16 years. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%).16 However, more recent studies of estriol have shown reported efficacies between 83% and 89.8%, similar to that of phenylpropanolamine.17,18. The information is NOT to be used for diagnosis or treatment of your pet. Madison, NJ: Intervet Inc.; 2011. Powered by Invision Community. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Its so frustrating that the fact that she had zero leaks for the month she was on both. Through phone tag with his office, he gave us a prescription for incurin to try as well as refilled our proin prescription. 2. Do not give possible diagnoses that could explain the symptoms described by OP. Dr. Snell is a third-year internal medicine resident at the Ohio State University College of Veterinary Medicine. -- Ernest Hemmingway. Kari and the pups.Run free sweet Hana 9/21/08-9/12/10. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. Dogs with a predilection for high blood pressure. Unfortunately as of a month ago it I have never liked it much since it is pretty much doggie speed and we very gingerly had to build up her dosage so it was not overwhelming for her. See our advertising disclosure. Sci. Similarly, increasing urethral length carries potentially serious surgical risks and, in the author's view, should be reserved for animals with severe congenital urethral hypoplasia. For further information, including complete directions and warnings, please see the fullprescribing information. Drug interactions are possible if using Proin in conjunction with the following medications: Always store Proin in accordance with the manufacturers instructions at room temperature and away from heat, light, and moisture. We really want to switch her over to something new and our vet recently suggested Incurin. Urinary Incontinence in the Male and Female Dog or Does Sex Matter? Of these, alpha-adrenergics gave the best results but, even then, more than half of the dogs failed to respond to therapy. Note: Any trademarks are the property of their respective companies. 1991;53:497-508. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. PRN Pharmacal. Hmm, good input - thank you! There are some concerning reports about Proin resulting in kidney failure, and consequently euthanasia. 59, 673-679. Schedule, update or cancel anytime, Reliable Anybody can detect what this is on a dog? There is considerable variation in urethral length between bitches of different sizes. Byron JK, March PA, Chew DJ, DiBartola SP. Incurin contains the active substance estriol. That will teach you to keep your mouth shut." Cloudflare Ray ID: 78ba5a30ef73efb4 WebThe Incurin (estriol) is typically not a first-line treatment for urinary incontinence, which is probably why it is only being tried now that Proin is no longer working. Arnold S. Urinary incontinence in castrated bitches. Accessed If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. Expand section Collapse section A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. Please see theproduct labelfor full prescribing information. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. ), is preferable for patients with known behavioral concerns. are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, and seizures. A urodynamic and clinical evaluation. J. Vet. 139, 542-546. Dogs on meds with known drug interactions. I have an 11 y/o German shepherd. The information is NOT to be used for diagnosis or treatment of your pet. 13. Dr. Snell received her DVM from Texas A&M University and has completed a rotating internship at Louisiana State University. Some limitations and restrictions may apply. Then COVID hit, and her vet stopped seeing us in person. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Here is the link: http://www.i-love-dogs.com/forums/doroin-read.html Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. 21. After the lowest daily dose that controls urinary incontinence is identified, the dose may be decreased further by administering once every 2 days. 2022 Veterinarian.org, LLC. The action you just performed triggered the security solution. Used hospital pads. Your IP: WebSwitching from Proin to Incurin So my girl has been incontinent since the day I brought her home. prnpharmacal.com/products/urinary-health/proin-chewable-tablets. 17. Create an account to follow your favorite communities and start taking part in conversations. If you buy something from a link on our site, we may earn a commision. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. JAVMA. Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. a liquid formulation of phenylpropanolamine, Propalin (Vetoquinol. NADA 141-324. Sympathomimetics (Ephedrine, Epinephrine), Drugs for high blood pressure meds (Reserpine), Anesthetics (Isoflurane, Desflurane, Sevoflurane), Monoamine oxidase inhibitors or MAOIs (Anipryl). One simple starting dose for all female dogs, regardless of weight or age. WebProin vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all She gradually started leaking more over the last year. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. These effects are reversible after lowering the dose. I've bought them in bulk on ebay. Were sorry, but our website doesnt work properly without JavaScript enabled. WebIncurin is made by Merck Animal Health and is available in a 1 mg estriol (sometimes referred to as oestriol) tablet. Never double dose your dog as high Phenylpropanolamine levels are toxic. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. After a month, the vet office called and said they accidentally filled both prescriptions and that she should only be on the incurin. Incurin is another FDA-approved This is very gross, and I never get answers when I ask What turned into an appointment for eye drops, turned Our super old dog is really skinny but otherwise fine. WebThere have never been head-to-head trials with Diethylstilbestrol (DES) or Incurin. In extra sensitive dogs, Proin may trigger an allergic reaction with symptoms like hives, facial swelling (lips, tongue), and breathing difficulties. Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. However, taking body size into consideration, bitches with sphincter mechanism incompetence tend to have shorter urethras than continent animals. So my girl has been incontinent since the day I brought her home. I do like that the DES can be given less frequently than the Incurin but it seems that both are low dose which is good. Proin for Dogs: A Simple Solution for Urinary Incontinence, Yes, you can give your dog Proin for control of urinary incontinence. 7. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. Freedom of Information Summary. NADA 141-324. Vet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. Related Topics . Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. (1985) Importance of urethral length, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism incompetence in the incontinent bitch. The recommended dose of Proin ER is 2 to 4mg/kg PO q24h (to be given with food).10 Proin ER is available in 18-, 38-, 74-, and 145-mg tablets. Atalan, G., Holt, P.E. WebProduct Description Incurin uses short-acting estrogen to treats spayed female dogs with urinary incontinence. WebProven effective in reducing or eliminating urinary incontinence. in dogs having had the ovaries and uterus removed surgically). Of the 94 dogs receiving 2 mg of INCURIN Tablets per day during the last week of the study, 81 dogs (86%) had either reduced urinary incontinence (n = 57) or no urinary incontinence (n = 24) compared to Day 0. Dogs can stay on Proin for over 180 days without developing serious issues. Currently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Vtoquinol). ), is available. Leakage of urine is more copious compared to animals with ureteral ectopia and occurs predominantly when the dogs are recumbent. I had switched her to a new practice that was closer to In addition to these common adverse reactions, some dogs develop more serious side effects, such as tremors, seizures, collapse, stroke-like symptoms (loss of coordination, abnormal gait, inability to walk), elevated liver enzymes, blood in urine, urinary retention, and kidney failure. Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. Cancel or update at anytime. The vet will determine the dogs usual dose. 69.163.186.88 Ahlstrm K, Sandahl B, Sjberg B, et al. 14. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. As in the bitch, the acquired form often follows neutering and larger breeds appear to be at risk. Thus, any increase in intravesical pressure is counteracted by an increase in urethral resistance. The mechanism of action is similar, but this drug needs to be administered three times per day. JAVMA. Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E. Also, do you know why it may be safer than DES? *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. U.S. Food and Drug Administration Center for Veterinary Medicine. Those that do not may be candidates for medical or surgical management (see acquired sphincter mechanism incompetence). Copyright 2023 PetMed Express, Inc. All Rights Reserved. 22. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. PRN Pharmacal. A similar variation in response is also seen with the use of alpha-adrenergic drugs Oestrogens sensitise the urethral smooth muscle to alpha-adrenergic stimulation and so a combination of oestrogen and alpha-adrenergic therapy may be useful and reduce the dose of each individual drug, lessening the chances of side effects. Please enable JavaScript in order to continue using our website. Sounds like your vet was having you give Incurin at the DES frequency. Two weeks and no adverse side effects. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. 15. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. Pract. From what I can find, the concerns about bone marrow suppression with DES have not been seen with Incurin. 1987;64(4):117-118. Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs. Scott L, Leddy M, Bernay F, Davot JL. Gilbert-Barness E, Drut RM. Stay current with the latest techniques and information sign up below to start your FREE Todays Veterinary Practice subscription today. (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Forsee KM, Davis GJ, Mouat EE, et al. same with Rainey, woke up to a soaking wet bed got her in right after and they started the DES. Please enable JavaScript in order to continue using our website. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants. Clark JH, Hardin JW, McCormack SA. In comparison with the bitch, the condition is less likely to respond to medical therapy. 3 x 3. I found this site with info about Incurin in Europe. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). I believe it's been used in Europe for a while and seems to be safer than DES. In talking to the vet office, they dont put dogs are both - their policy not specific to my dog. This only started near the end (and the seizures), before that she never did that in the house. Two weeks later, she is back to leaking. It can present as a congenital or acquired condition. 2 For the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. Proin chewable tablets are available in different strengths 25 mg tablets, 50mg tablets, and 75mg tablets. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. 3. My only reservation is that the Incurin is new and they do not know the long term effects just yet. Sometimes switching foods, to a non-grain food can help. I think the Incurin will be a good option. 17. Proin chewable tablets. Please be aware that estriol and phenylpropanolamine products should not be imported from other countries for use in animals. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants.7 Phenylpropanolamine should not be given within 2weeks of a patient receiving a monoamine oxidase inhibitor such as amitraz.7 Finally, anesthesia with halothane is associated with an increased risk of arrhythmias and should be avoided.7, In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. Am. We have to get something better!! During the procedure, the vagina is stretched cranially and anchored on either side of the urethra to the prepubic tendon. WebFind honest and helpful reviews for Incurin (Estriol) Tablets for Dogs, 1-mg at Chewy.com. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls. Keep in mind that the info in this article is purely educational. A place where you can ask veterinary medicine related questions and get advice from veterinary professionals. It does have different side effects. Proin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. Vet. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Please contact the moderators of this subreddit if you have any questions or concerns. Power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E. Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. 6. In case you forgot to give your dog Proin, give the soft chew as soon as you remember. You could see a positive change in the dogs mood - perfect. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). (1990) Long-term evaluation of colposuspension in the treatment of urinary incontinence due to incompetence of the urethral sphincter mechanism in the bitch. Nendick PA, Clark WT. Part 1: significance, clinical aspects and etiopathogenesis [in German]. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. We would just distract her in the other room while the other one discreetly cleaned up. Phenylpropanolamine is effective at improving continence in dogs with USMI. Accessed October 2020. Diethylstilbestrol (DES) is a commonly used synthetic, long acting estrogen, but it is not labeled for use in animals and is only available as a compounded product. 15% discount available for new customers only. I prefer DES--with the low dose used for urinary Incontinence side effects are very, very rarely seen. 2013;242(7):959-962. Yes, you can give your dog Proin for control of urinary incontinence. The additional benefit is that Incurin is FDA approved and commercially available while DES has to be compounded. Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice In other words, Pehnylpropranolamine works by constricting the bladder sphincter muscle, thus preventing urine leakage. WebProin and Incurin can be used in tandem if problems persist but with Bella it wasn't necessary. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? The most common side effects 2. Special stock for AutoShip customers. Weber, U. T., Arnold, S., Hubler, M. & Kupper, J.R. (1997) Surgical treatment of male dogs with urinary incontinence due to urethral sphincter mechanism incompetence. 8. thanks! (2001) Urethropexy for the management of urethral sphincter mechanism incompetence in the bitch. 13. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. Holt,P.E .&Thrusfield,M.V. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. 1997;139(6):271-276. Care is taken to avoid compression of the urethra during the technique. Biopharm Drug Dispos. Greytalk.com Due to toxicity risks, the bottles of Proin must be kept in a secured location (out of reach of dogs and out of reach of children). IMO routine blood pressures are a lacking 1. Forsee KM, Davis GJ, Mouat EE, et al. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Flexible The version from Pegasus laboratories comes in 18 mg, 38 mg, 74 mg, and 145 mg. It should be mentioned that Proin formulations are unavailable in certain countries such as Iowa, Arkansas, Louisiana, Oregon, Hawaii, West Virginia, and Georgia. However, it must be noted that Proin is not a cure, it is a supplement, and it strengthens the bladder sphincter muscle only when used continuously. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Cancel or update at anytime. Vet Hum Toxicol 2000;42(3):168-171. 9th ed. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). Vet. Association of sympathomimetic drugs with malformations. 1988;32(2):273-280. Arnold S. Urinary incontinence in castrated bitches. In humans and certain animal species, sympathomimetic drugs are linked with birth defects, but the issue is not confirmed in pets. (1993)The association between breed, size, neutering, docking and acquired urinary incontinence due to urethral sphincter mechanism incompetence in bitches.
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